SOBRE EL PAPEL DE LA FARMACOMÉTRICA Y EL OBJETIVO DE OPTIMIZAR EL CÁNCER TERAPIAS

Abstract

n the optimization of mathematical models for cancer chemotherapies, the controls are given by the drug-dosages and the objective minimizes some compromise between tumor kill and side effects. In simple models, the dosage, concentration and effect of the drugs are identified. Here we discuss the role of pharmacometric models which describe the links between these quantities. The choice of the mathematical representation of the objective also has an effect on the solutions of the problem. Both of these aspects will be discussed.