ONCOLOGY DOSAGE TOOLS BASED ON THE STATISTICAL MODELS PROJECT (SMp) MODELS

Abstract

Purposes: 1) To establish a new methodology for evaluating efficacy and toxicity in chemotherapy (CTX) following the same probabilistic principles that have been used in the radiation oncology therapies (ROTs) in the tumor control/normal tissue complication probability
(TCP/NTCP). In CTX, the sickness control probability (SCP) and a NTCP1 (NTCP for CTX) function of a dose of reference are proposed; 2) To establish a new methodology of dosage in CTX using optimal values of these proposed indices; 3) To provide SMp models for the stochastic processes (SPs) involved into the CTX; and 4) To develop simple computer tools using TCP, NTCP, SCP and NTCP1.
The following results were obtained: 1) Two Excel calculation sheets that determine the TCP and NTCP for the ROT using the SMp models; and evaluating until three organs at risk, as well as indices for a real CTX treatment, the SCP and NTCP1; and 2) SMp models for
SPs involved in CTX